Journal: bioRxiv
Article Title: Targeting Microbial Bile Salt Hydrolase Reprograms Bile Acid Metabolism and Ameliorates Metabolic Dysfunction–Associated Steatohepatitis in Mice
doi: 10.64898/2026.05.12.724693
Figure Lengend Snippet: a , Experimental design. Male C57BL/6 Foz/Foz mice were fed chow diet (CD) or western diet (WD). GR-7 was administered either as early intervention (EI) starting at week 3 of WD feeding or as late intervention (LI) starting at week 12, at low (0.034%) or high (0.1%) dietary doses. Group sizes are indicated. b , Longitudinal food intake during early intervention. c , Cumulative food intake during early intervention. d , Longitudinal food intake during late intervention. e , Cumulative food intake during late intervention. f , Longitudinal body weight gain during early intervention. g , Longitudinal body weight gain during late intervention. h , Cumulative body weight gain during early intervention. i , Cumulative body weight gain during late intervention. j , Short-term dietary GR-7 intervention schematic in WD-fed wild-type mice. k , Daily food intake following short-term dietary GR-7 treatment. l , Body weight gain during short-term dietary GR-7 treatment. m , Oral gavage intervention schematic in WD-fed wild-type mice receiving PBS or GR-7. n , Daily food intake following oral gavage of PBS or GR-7. o , Body weight gain following oral gavage of PBS or GR-7. Data are shown as mean ± SD. Each symbol represents one mouse/one cage. Statistical significance was determined by one-way ANOVA with Bonferroni’s multiple-comparisons test. For comparisons between two groups, Mann–Whitney U test was used. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001.
Article Snippet: Wild-type male C57BL/6 mice (6 weeks of age) were obtained from Charles River Laboratories and fed a WD for 5 weeks.
Techniques: Western Blot, MANN-WHITNEY
